Retinal Layer Thinning May Predict Relapse Remission in MS – Consumer Health News

THURSDAY, Aug. 18, 2022 (HealthDay News) — Retinal layer thinning after optic neuritis (ON) could also be helpful as a marker of future relapse remission in relapsing a number of sclerosis (MS), in keeping with a examine printed on-line Aug. 2 in Neurology.

Gabriel Bsteh, P.D., M.D., Ph.D., from the Medical University of Vienna, and colleagues used knowledge from the Vienna MS database to analyze whether or not retinal thinning after ON is related to relapse remission after subsequent non-ON relapses. The evaluation included 167 MS sufferers with an episode of acute ON and accessible spectral-area optical coherence tomography (OCT) scans inside 12 months earlier than ON onset (OCT_baseline), inside one week after ON onset (OCT_acute), and at three to 6 months of observe-up (OCT_observe-up).

The researchers discovered that in a imply of three.4 years of observe-up after the ON episode, 36.5 % of sufferers had not less than one relapse that confirmed incomplete remission. Incomplete remission of non-ON relapse was related to macular ganglion-cell-and-interior-plexiform-layer thinning each from OCT_baseline to OCT_observe-up and from OCT_acute to OCT_observe-up (odds ratio [OR], 2.4 per 5 µm), independently explaining 29 and 27 % of variance, respectively. Change in retinal thinning in the peripapillary retinal nerve fiber layer from OCT_baseline to OCT_observe-up additionally was related to incomplete relapse remission (OR, 1.9 per 10 µm), which independently accounted for 22 % of variance.

“In retinal layer thickness, we have now discovered a brand new biomarker that represents a window to the mind, because it had been,” Bsteh stated in an announcement.

Several authors disclosed monetary ties to pharmaceutical corporations.

Abstract/Full Text